As novice certified registered nurse anesthetists (CRNAs) and other advanced practice registered nurses (APRNs) transition into independent practice, they experience increased stress and psychological challenges that may decrease job satisfaction and increase the likelihood that they leave their jobs within the first year. Retaining anesthesia providers is of paramount importance to healthcare organizations that wish to reduce operating costs and maintain patient access to care. To enhance job satisfaction and the retention of CRNAs (and other APRNs), scholars argue that new graduates may need help transitioning into the workforce through transition to practice (TTP) programs. The purpose of this DNP project was to conduct a systematic review of the literature to synthesize evidence related to the effectiveness of TTP programs and to determine which individual components are frequently included in such programs. Nine studies met inclusion criteria. Results indicate that TTP programs are associated with increased job satisfaction and retention for APRNs, and typically include components such as mentorship, didactic training, and ongoing evaluation. Findings are discussed regarding the strength of these relationships and directions for future research.