Nurses face a disproportionately high risk of workplace violence (WPV), more than police officers and prison guards, with approximately 70% of assaults occurring in the healthcare setting. Despite this trend, there is a gap in standardized, evidence-based training for inpatient nurses. Effective management of WPV is multifactorial, with evidence indicating that a combination of training, screening, prevention planning, and organizational response is essential. Aim: This QI project revised the WPV prevention protocol on a medical-surgical unit by introducing an evidence-based risk-for-violence screening tool and in-person de-escalation training. Method: Using the Plan-Do-Study-Act (PDSA) framework, 37 nurses received a 30-minute de-escalation training and completed pre- and post-de-escalation training confidence assessments. The Broset Violence Checklist (BVC) was employed to categorize patients upon admission as low, moderate, or high risk for violence. High-risk patients were discussed in pre-shift staff huddles, and nurses received proactive daily rounds from security. Results: Findings indicated that of the 443 screenings completed, 87% (N=393) scored as low risk, 10% (n=45) as moderate risk, and less than 1% (n=5) as high risk. Notably, there were no reported WPV incidents during the six-week project period, and five potential incidents resulted in no assault or injury after the initiation of the new protocol. Nurse confidence levels increased with the revised protocol and training, especially in the areas of organizational support and security rounding. Conclusion: Proactive identification of patients at risk for violence can reduce assaults against nurses. Security rounding on nurses for high-risk patients enhances perceived safety and confidence in the workplace.