The lack of opioid withdrawal (OW) treatment protocols in hospitals has been shown to increase patient length of stay, readmission rates, and rates of patients leaving against medical advice (AMA). Nurses play a crucial role in providing high-quality care to patients affected by opioid use disorder (OUD) and OW. However, some nurses may lack motivation to care for patients with OUD due to a lack of education, stigma, and potential biases associated with this patient population. The purpose of the project was to implement a nurse-driven OW protocol that incorporated the Clinical Opiate Withdrawal Scale (COWS) and evaluate nurses’ perceptions of their attitudes toward patients with OUD using the Drug and Drug Users’ Problems Perceptions Questionnaire (DDPPQ). A pre- and post-education survey was distributed to assess nurses’ attitudes toward patients with OUD using the DDPPQ. Additionally, patient chart audits were conducted to determine whether the implementation of the COWS protocol improved patient outcomes. Thirty-three nurses completed the pre-education DDPPQ, while ten nurses completed the post-education DDPPQ. The results indicated an improvement in nurses' attitudes toward patients with OUD after they received education on OW treatment. Although the DDPPQ results did not show statistical significance, there was clinical significance. The project showed that when given an education nurses' attitudes toward patients with OUD can change. Future research should focus on evaluating patient OW symptoms in the emergency department (ED) and evaluate whether stigma directly affects nurses’ motivation to work with patients with OUD.